Selective Estrogen Receptor Degrader GDC-0927

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available, nonsteroidal selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon oral administration, SERD GDC-0927 specifically binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This prevents ER-mediated signaling and inhibits the growth and survival of ER-expressing cancer cells.

**Synonyms:** - GDC 0927 - GDC-0927 - GDC-0927 - GDC0927 - RG 6047 - RG-6047 - RG6047 - SERD GDC-0927 - SERD RG6047 - SERD SRN-927 - SRN 927 - SRN-927 - SRN927