Fluorine F 18-labeled 2-FACPC

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of an analog of the synthetic, alicyclic amino acid aminocyclopentane carboxylic acid (ACPC) radiolabeled with the positron-emitting isotope fluorine F 18 (2-[18F]FACPC), with potential cancer cell imaging activity during positron emission tomography (PET). As tumor cells have a higher rate of protein synthesis than normal, healthy cells, upon administration, fluorine F 18 labeled 2-FACPC is selectively taken up by rapidly proliferating tumor cells through the sodium-independent subtype L amino acid transport system (AAT) which leads to the accumulation of this tracer in tumor cells. Upon PET, tumor cells can then be visualized.

**Synonyms:** - 1-Amino-2-[18F]fluorocyclopentane-1-carboxylic Acid - 2-[(18)F]FACPC - 2-[18F]FACPC - Anti-1-amino-2-[18F]fluorocyclopentyl-1-carboxylic Acid - Anti-2-[(18)F]FACPC