Hereditary Nonpolyposis Colorectal Cancer Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** An inherited syndrome characterized by the development of several cancers, particularly colon and rectal cancers. It includes Lynch syndrome which is associated with germline mutations in DNA mismatch-repair genes and familial colorectal cancer type X which is characterized by the absence of germline mutations in DNA mismatch-repair genes.

**Synonyms:** - Familial Nonpolyposis Colorectal Cancer Syndrome - HNPCC - HNPCC - Hereditary Non-polyposis Colon Cancer - Hereditary Nonpolyposis Colorectal Cancer - Hereditary Nonpolyposis Colorectal Cancer (HNPCC) - hereditary nonpolyposis colon cancer