Roblitinib

**Semantic type:** Pharmacologic Substance

**Definition:** An inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, roblitinib binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival.

**Synonyms:** - FGF401 - FGFR4 Inhibitor FGF401 - ROBLITINIB