Elacestrant

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available, selective estrogen receptor degrader (SERD), with antineoplastic activity. Upon oral administration, elacestrant acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the proteosomal degradation of the receptor. This prevents ER-mediated signaling and inhibits proliferation of ER-expressing cancer cells.

**Synonyms:** - (6R)-6-(2-(Ethyl((4-(2- (ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)- 5,6,7,8-tetrahydronaphthalen-2-ol - ELACESTRANT - ER-306323 - RAD 1901 - RAD-1901 - RAD1901 - SERD/SERM RAD1901