Homologous Recombination Deficiency

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A DNA repair abnormality caused by mutations in one or more genes that are involved in homologous recombination repair. Deficient homologous recombination is associated with numerous neoplastic diseases and developmental disorders related to chromosomal nondisjunction.

**Synonyms:** - HRD - HRR Deficiency - Homologous Recombination Repair Deficiency