Lifileucel

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous tumor infiltrating lymphocytes (TILs), with potential antineoplastic activity. TILs are isolated from a patient's tumor tissue, cultured in vitro with high-dose interleukin-2 (lL-2), further selected based on antigen specificity and tumor reactivity, and the selected TILs are subsequently expanded. Upon re-introduction of lifileucel into the patient, the TILs re-infiltrate the tumor, specifically recognize the tumor-associated antigens (TAAs), and initiate tumor cell lysis. IL-2 induces the proliferation and expansion of TILs in vitro.

**Synonyms:** - Amtagvi - Autologous TIL LN-144 - Autologous Tumor Infiltrating Lymphocytes LN-144 - Contego - LIFILEUCEL - LN 144 - LN-144 - LN144 - Lifileuecel