Pyrazofurin

**Semantic type:** Antibiotic|Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04)

**Synonyms:** - .beta.-Pyrazomycin - 1H-Pyrazole-5-carboxamide, 4-Hydroxy-3-beta-D-ribofuranosyl- (9CI) - 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-.beta.-D-ribofuranosyl- (9CI) - 4-Hydroxy-3-.beta.-D-ribofuranosylpyrazole-5-carboxamide - 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide - 47599 - 47599 - Beta-Pyrazomycin - Compound 47599 - PRZF - PYRAZOFURIN - PYRAZOFURIN - Pirazofurin - Pirazofurin - Pyrazole, -3-Carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl - Pyrazole, -3-carboxamide, 4-hydroxy-5-.beta.-L-ribofuranosyl- - Pyrazomycin - Pyrazomycin