Chronic Progressive Nephropathy

**Semantic type:** Disease or Syndrome

**Definition:** A spontaneous, age-related renal disease of rats, characterized by morphological changes such as degeneration of the epithelium lining of the tubules, thickening of glomerular, Bowman and proximal tubular basement membranes, and lesions in the glomeruli leading to mesangial overload and glomerulosclerosis.

**Synonyms:** - CHRONIC PROGRESSIVE NEPHROPATHY