Fibroblast Growth Factor Receptor Family Isoform IIIc

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme|Receptor

**Definition:** An isoform of fibroblast growth factor receptor-1, -2, or -3, where alternative splicing leads the expression of the IIIc exon encoding the second half of the third immunoglobulin-like domain, which is located in the extracellular domain of these receptors. This variant is expressed in mesenchymal lineage cells and has differential ligand binding activity when compared to the IIIa and IIIb forms.

**Synonyms:** - FGFR IIIc - FGFR-IIIc - Fgfr(IIIc)