Gallium Ga 68-labeled RM2

**Semantic type:** Amino Acid, Peptide, or Protein|Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radioconjugate containing a synthetic bombesin receptor antagonist targeting the gastrin-releasing peptide receptor (GRPR), that is linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68 GRPR antagonist BAY86-7548, the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor 2 (BB2), is a G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.

**Synonyms:** - (68)Ga-DOTA-4-amino-1-carboxymethylpiperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 - 68-Ga RM2 - 68Ga-Bombesin Antagonist BAY86-7548 - 68Ga-DOTA RM2 - 68Ga-DOTA-Bombesin Analog BAY86-7548 - 68Ga-RM2 - BAY 86-7548 - Ga-68-labeled Bombesin Antagonist BAY 86-7548 - Gallium Ga 68-labeled GRPR Antagonist BAY86-7548 - Gallium Ga68-labeled GRPR Antagonist RM2 - RM-2 GA-68 - [68Ga]-labeled Bombesin Analog BAY86-7548 - [68Ga]RM2