Giant Cell Tumor of Bone

**Semantic type:** Neoplastic Process

**Definition:** A locally aggressive tumor that arises from the bone and is composed of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It usually arises from the ends of long bones or the vertebrae. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.

**Synonyms:** - Benign Bone Giant Cell Tumor - GCTB - GIANT CELL TUMOR, BENIGN - Giant Cell Tumor of the Bone - Giant cell tumor of bone, NOS - Osteoclastoma - Osteoclastoma, Benign