Samarium Sm-153 Lexidronam Pentasodium

**Semantic type:** Pharmacologic Substance

**Definition:** The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases.

**Synonyms:** - Quadramet - Quadramet - SAMARIUM SM-153 LEXIDRONAM PENTASODIUM - Samarium Sm 153 Lexidronam Pentasodium - Samarium Sm-153 EDTMP Pentasodium - Samarium-153 EDTMP Pentasodium - Sm 153 Lexidronam Pentasodium - samarium Sm 153 lexidronam pentasodium