GW776/5-Fluorouracil Combination Tablet

**Semantic type:** Therapeutic or Preventive Procedure

**Definition:** A tablet formulation containing 5-ethynyluracil (GW776), an ethynyl derivative of uracil and the antineoplastic agent 5-Fluorouracil (5-FU) in a 10:1 ratio. The GW776 portion of the tablet inhibits dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in 5-FU catabolism, thereby blocking degradation of 5-FU in the gastrointestinal tract and increasing the bioavailability of 5-FU. (NCI04)

**Synonyms:** - GW776/5-FU Combination Tablet