Hardcastle's Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** A rare, autosomal dominant inherited dysplasia of the long bones, characterized by symmetrical diaphyseal medullary stenosis, bone infarctions, pathologic fractures, and a high risk of development of malignant fibrous histiocytoma.

**Synonyms:** - DMS-MFH - Diaphyseal Medullary Stenosis with Malignant Fibrous Histiocytoma