Acute Myeloid Leukemia with inv(3)(q21.3;q26.2); GATA2, MECOM

**Semantic type:** Neoplastic Process

**Definition:** An acute myeloid leukemia associated with inv(3)(q21.3q26.2) resulting in the reposition of a distal GATA2 enhancer to activate MECOM expression. It may present de novo or follow a myelodysplastic syndrome. The clinical course is aggressive.

**Synonyms:** - Acute Myeloid Leukemia with inv(3) (q21.3;q26.2); GATA2, EVI1 - Acute Myeloid Leukemia with inv(3) (q21.3;q26.2); GATA2, MECOM - Acute Myeloid Leukemia with inv(3) (q21.3;q26.2); GATA2, MECOM(EVI1) - Acute Myeloid Leukemia with inv(3)(q21.3;q26.2); GATA2::MECOM - Acute Myeloid Leukemia with inv(3)(q21q26.2); RPN1-EVI1