Anti-human Cytomegalovirus Monoclonal Antibody Combination CSJ-148

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A combination agent composed of two human monoclonal antibodies against the human cytomegalovirus (HCMV), LJP538 and LJP539, with potential immunomodulating activity. Upon administration of CSJ-148, both LJP538 and LJP539 bind to and inhibit the function of viral HCMV glycoproteins that are essential for HCMV infection; LJP538 targets and binds to glycoprotein B (gB) and LJP539 targets and inhibits the pentameric complex, consisting of glycoproteins gH, gL, UL128, UL130, and UL131. Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients.

**Synonyms:** - Antiviral Agent CSJ148 - CSJ 148 - CSJ-148 - CSJ148 - HCMV Neutralizing Human mAb Combination CSJ-148 - LJP538 Plus LJP539 - LJP538 and LJP539 - LJP538/LJP539