Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein Family

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A family of membrane bound proteins comprised of 15 leucine-rich repeats that are flanked both N- and C- terminally by cysteine-rich regions, three C2-type immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. The members of this protein family may be involved in the suppression of growth factor receptor signaling.

**Synonyms:** - LIG - LIG Family - LRIG - LRIG Family - Leucine-Rich Repeats and Immunoglobulin-Like Domains Protein