Selective Estrogen Receptor Degrader AZD9496

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally available selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon administration, SERD AZD9496 binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This prevents ER-mediated signaling and inhibits the growth and survival of ER-expressing cancer cells.

**Synonyms:** - (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid - AZD 9496 - AZD-9496 - AZD-9496 - AZD9496 - SERD AZD9496