Sodium Thiosulfate

**Semantic type:** Inorganic Chemical|Pharmacologic Substance

**Definition:** A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04)

**Synonyms:** - Cyanide Antidote Package - Disodium Thiosulfate - Disodium thiosulfate - S-Hydril - S-Hydril - SODIUM THIOSULFATE - Sodium Hyposulfate - Sodium Thiosulfate Pentahydrate - Sodium Thiosulphate - Sodium thiosulfate - Sodothiol - Thiosulfate, Sodium, Pentahydrate - Thiosulfuric Acid Disodium Salt - Thiosulfuric acid disodium salt - sodium thiosulfate