Glibornuride

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable sulfonamide urea derivative with antihyperglycemic activity. Upon administration, glibornuride binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward flow of positively charged potassium (K+) ions into the cell, and induces a calcium ion (Ca2+) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules. Insulin stimulates glycogen synthesis and inhibits gluconeogenesis, which together lower blood glucose levels.

**Synonyms:** - 1-((1R)-2-endo-hydroxy-3-endo-bornyl)-3-(p-tolylsulfonyl)urea - GLIBORNURIDE - Glutril - Ro 6-4563 - Ro 6-4563/8 - Urea, 1-(2-Hydroxy-3-bornyl)-3-(p-tolylsulfonyl)-, (1R,2R,3S,4S)-