Multicentric Osteolysis, Nodulosis, and Arthropathy

**Semantic type:** Disease or Syndrome

**Definition:** A rare, autosomal recessive inherited syndrome caused by mutations in the MMP2 gene. It is characterized by the presence of multiple, painless subcutaneous nodules, osteolysis particularly in the hands and feet, osteoporosis, and arthropathy.

**Synonyms:** - Hereditary Multicentric Osteolysis - MONA