Anti-FGFR3 Antibody-drug Conjugate LY3076226

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC) composed of a human monoclonal antibody against the fibroblast growth factor receptor type 3 (FGFR3) that is conjugated to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration, the antibody moiety of anti-FGFR3 ADC LY3076226 binds to FGFR3. Upon internalization, the cytotoxic moiety causes cell death in FGFR3-expressing tumor cells. FGFR3, a receptor tyrosine kinase upregulated or mutated in many tumor cell types, plays a key role in tumor cell proliferation.

**Synonyms:** - ADC LY3076226 - Anti-FGFR3 ADC LY3076226 - Anti-fibroblast Growth Factor Receptor 3 Antibody-Drug Conjugate LY3076226 - LY-3076226 - LY3076226