8-Chloroadenosine

**Semantic type:** Pharmacologic Substance

**Definition:** An antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro-adenosine is phosphorylated to form 8-chloro-adenosine triphosphate (8-chloro-ATP), which functions as a ribonucleoside analogue and competes with ATP during transcription. Therefore, this agent causes RNA synthesis inhibition, inhibits cellular proliferation, and induces apoptosis.

**Synonyms:** - 8-CHLOROADENOSINE - 8-Chloro-adenosine - 8-Cl-Ado - 8-Cl-adenosine - Adenosine, 8-Chloro-