High Occupancy Target Region

**Semantic type:** Nucleotide Sequence

**Definition:** A regulatory element that is a target for a large number of transcription regulatory proteins. These DNA sequences, which play a role in the regulation of gene expression, bind to transcription factors or coregulatory proteins at a higher density than would be expected by chance.

**Synonyms:** - HOT Region - High Occupancy of TRF Region - High Occupancy of Target Region - High Occupancy of Transcription-Related Factors Region - High-Occupancy Target Region