Anti-MUC1 CAR-transduced Autologous T-lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) against the human tumor-associated epithelial antigen mucin 1 (MUC1), with potential immunomodulating and antineoplastic activities. Autologous PBLs from a patient with MUC1-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for MUC1. After expansion in culture and reintroduction into the patient, anti-MUC1 CAR-transduced autologous T-lymphocytes target and induce selective toxicity in MUC1-expressing tumor cells. MUC-1 is a human, hypoglycosylated tumor-associated antigen (TAA) overexpressed by epithelial cancer cells.

**Synonyms:** - Anti-MUC1 Autologous CAR T Cells - Anti-MUC1 CAR-transduced Autologous T Cells - Anti-Mucin1 Autologous CAR T Cells