Ormaplatin

**Semantic type:** Inorganic Chemical|Pharmacologic Substance

**Definition:** A platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity.

**Synonyms:** - ORMAPLATIN - Platinum, tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))- - Tetraplatin - Tetraplatin - tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))Platinum