TREM2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TREM2 wild-type allele is located in the vicinity of 6p21.1 and is approximately 5 kb in length. This allele, which encodes triggering receptor expressed on myeloid cells 2 protein, is involved in inflammation. Expression of the gene may be associated with chronic inflammation and mutation of the gene is associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease).

**Synonyms:** - TREM-2 - Trem2a - Trem2b - Trem2c - Triggering Receptor Expressed On Myeloid Cells 2 wt Allele - Triggering Receptor Expressed On Myeloid Cells 2a Gene