Vortioxetine Hydrobromide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine.

**Synonyms:** - 1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl)piperazine Monohydrobromide - Brintellix - Piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)-, Hydrobromide (1:1) - Trintellix - VORTIOXETINE HYDROBROMIDE