Trilostane

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04)

**Synonyms:** - (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile - 2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one - 4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile - Desopan - Modrastane - Modrenal - TRILOSTANE - WIN 24,540 - WIN 24540