Chronic Active EBV Disease

**Semantic type:** Neoplastic Process

**Definition:** An EBV-positive T-cell/NK-cell lymphoproliferative disorder characterized by repeated infectious mononucleosis-like symptoms, a very high titer of anti-EBV antibodies, and high levels of Epstein-Barr virus nucleic acids. Patients often develop progressive cellular and humoral immunodeficiency with pancytopenia and hypogammaglobulinemia.

**Synonyms:** - CAEBV - CAEBV Infection - Chronic Active EBV Infection - Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form - Chronic Active Epstein-Barr Virus Disease - Chronic active Epstein-Barr virus (without identified mutation) - Systemic CAEBV of T-and NK-Cell Type - Systemic Chronic Active EBV Disease - Systemic Chronic Active EBV Infection of T-Cell and NK-Cell Type