Anti-VEGF/ANG2 Nanobody BI 836880

**Semantic type:** Pharmacologic Substance

**Definition:** A nanobody directed against angiopoietin-2 (Ang2; ANGPT2)- and vascular endothelial growth factor (VEGF)-derived peptides, with potential antiangiogenic and antineoplastic activities. Anti-VEGF/ANG2 nanobody BI 836880 binds to Ang2 and VEGF and inhibits receptor binding; this prevents Ang2- and VEGF-mediated signaling and inhibits both tumor angiogenesis and tumor cell proliferation. Both VEGF and Ang2 are upregulated in a variety of cancer cell types and play a crucial role in angiogenesis. The nanobody is based on functional fragments of single-chain antibodies.

**Synonyms:** - Anti-VEGF/ANG2 BI 836880 - BI 836880 - BI-836880 - Bi-specific Anti-VEGF/Ang2 Nanobody BI 836880