Iodine I 123 RISAD-P

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate containing an androgen receptor (AR) targeting agent, 5-radioiodo-3'-O-(17beta-succinyl-5alpha-androstan-3-one)-2'-deoxyuridin-5'-yl phosphate (RISAD-P), labeled with the radioisotope iodine I 123 ([123]I-RISAD-P), with potential use as an imaging agent for single photon emission computed tomography (SPECT) imaging. Upon administration, iodine I 123 RISAD-P selectively binds to and is taken up by AR. Upon SPECT imaging, AR-expressing tumor cells can be imaged and AR expression levels can be assessed. AR, which is overexpressed on certain tumor cells, plays key roles in tumor cell growth and survival.

**Synonyms:** - (123) IRISAD-P - 123IRISAD-P - 5-[123I]iodo-3'-O-(17b-succinyl-5a-androstan-3-one)-2'-deoxyuridin-5'-yl Monophosphate - I 123 RISAD-P - RISAD-P I-123 - [123]I-5-Radioiodo-3'-O-(17beta-succinyl-5alpha-androstan-3-one)-2'-deoxyuridin-5'-yl Phosphate - [123]I-RISAD-P