Kava-based Supplement

**Semantic type:** Pharmacologic Substance

**Definition:** A Kava supplement derived from Piper methysticum and containing high amounts of kavalactones, with potential cancer preventative and anxiolytic activities and that may be used to facilitate tobacco cessation. Upon oral administration, the kava-based supplement may affect the metabolism of certain carcinogens, presumably because of the kavalactones present in this product. This increases detoxification of the carcinogens and may suppress carcinogen-induced DNA damage and may lower the risk of carcinogenesis. Intake of the kava-based supplement may also suppress stress-mediated protein kinase A (PKA) activation, and reduces plasma cortisol levels. This may induce relaxation, may relief stress and anxiety, improve sleep, and may help reduce tobacco use and tobacco dependence, and may ultimately decrease the risk of tobacco-associated lung carcinogenesis. The Kava-based supplement is free of flavokavains A and B, which are potential hepatotoxic ingredients in kava.

**Synonyms:** - AB-free Kava - Flavokavain A/Flavokavain B-free Kava Supplement - Flavokavains A and B-free Kava Supplement - Flavokavains A/B-free Kava Supplement - Kava Supplement - Kavalactones-based Supplement