Glucocorticoid Resistance

**Semantic type:** Finding

**Definition:** An autosomal dominant condition due to mutation(s) in the NR3C1 gene, encoding the glucocorticoid receptor, resulting in decreased receptor affinity to glucocorticoids. Compensatory activation of the hypothalamic- pituitary-adrenal (HPA) axis results in increased mineralocorticoid and androgen production; clinical manifestations of glucocorticoid deficiency are rare.

**Synonyms:** - Chrousos Syndrome - Generalized Glucocorticoid Resistance