2'-5'-Oligoadenylate

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide

**Definition:** An oligonucleotide synthesized from adenosine triphosphate (ATP) by enzymes in the 2'-5'-oligoadenylate synthase family. The production of 2'-5'-oligoadenylate is stimulated by the presence of double stranded RNA (dsRNA) and binds to inactive monomeric forms of ribonuclease L (RNase L), thereby promoting RNase L dimerization and activation. Active RNase L degrades both cellular and viral RNAs, which inhibits protein translation and leads to the abrogation of viral replication. 2'-5'-oligoadenylates play a key role in the innate immunity against viruses.

**Synonyms:** - 2'-5' Oligoadenylate - 2-5-Oligoadenylate - 2-5A