IGHV3-21 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human IGHV3-21 wild-type allele is located in the vicinity of 14q32.33 and is approximately 1 kb in length. This allele, which encodes the immunoglobulin heavy variable 3-21 protein, plays a role in the structure of immunoglobulin heavy chains. Expression of mutated IGHV3-21 in chronic lymphocytic leukemia may be associated with a poor prognosis.

**Synonyms:** - Homo sapiens Immunoglobulin Heavy Variable 3-21 Gene - IGHV321 - Immunogloblin Heavy Chain Variable Region 3-21 Gene - Immunoglobulin Heavy Variable 3-21 wt Allele - VH