Emapalumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg), with potential immunomodulating activity. Upon administration, emapalumab binds to and neutralizes IFNg. This inhibits IFNg-mediated signaling pathways and suppresses the activation of the immune system. IFNg, a cell-signaling protein, plays a key role in the regulation and activation of the immune system; its upregulation is associated with certain auto-immune and auto-inflammatory diseases in which the immune system is abnormally activated.

**Synonyms:** - Anti-IFN gamma Monoclonal Antibody NI-0501 - Anti-IFNg mAb NI-0501 - Anti-interferon gamma Monoclonal Antibody NI-0501 - EMAPALUMAB - Emapalumab-lzsg - Gamifant - NI 0501 - NI-0501 - NI0501