Recombinant Vascular Endothelial Growth Factor

**Semantic type:** Chemical Viewed Functionally

**Definition:** A recombinant therapeutic agent which is chemically identical to or similar to endogenous vascular endothelial growth factor (VEGF). Produced by a wide variety of cell types, endogenous VEGF is a homodimeric, glycosylated protein that is a highly specific mitogen for vascular endothelial cells; significantly influences vascular permeability; appears to play a role in neovascularisation under physiological conditions; is a potent chemoattractant; has pro-coagulatory activities; and is hypoxia-inducible. Therapeutic VEGF may be used to induce angiogenesis in the treatment of ischemic conditions and may have a role in stimulating nerve regeneration. (NCI04)

**Synonyms:** - VEGF - VPF - Vascular Endothelial Growth Factor - Vascular Permeability Factor - rhuVEGF - vascular endothelial growth factor