Ceftazidime/Avibactam Sodium

**Semantic type:** Antibiotic|Pharmacologic Substance

**Definition:** A combination preparation containing the third-generation cephalosporin ceftazidime and the sodium salt form of avibactam, a non-beta-lactam beta-lactamase inhibitor, with antibiotic and beta-lactamase inhibiting activity, respectively. Upon administration, ceftazidime binds to essential penicillin-binding proteins (PBPs) and inhibits cell wall synthesis in certain bacteria. Avibactam binds to and inactivates beta-lactamases, thereby protecting ceftazidime from degradation and increasing ceftazidime's efficacy.

**Synonyms:** - Avycaz - CAZ-AVI - Ceftazidime-Avibactam Sodium