Melanoma Antigen Preferentially Expressed in Tumors

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Melanoma antigen preferentially expressed in tumors (509 aa, ~58 kDa) is encoded by the human PRAME gene. This protein plays a role in the repression of retinoic acid receptor-dependent gene expression.

**Synonyms:** - Cancer/Testis Antigen 130 - OIP-4 - Opa-Interacting Protein 4 - Opa-Interacting Protein OIP4 - PRAME - Preferentially Expressed Antigen in Melanoma - Preferentially Expressed Antigen of Melanoma