Dabrafenib Mesylate

**Semantic type:** Pharmacologic Substance

**Definition:** The mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.

**Synonyms:** - DABRAFENIB MESYLATE - Dabrafenib Methanesulfonate - GSK2118436 Methane Sulfonate Salt - GSK2118436B - Tafinlar