Nemvaleukin Alfa

**Semantic type:** Pharmacologic Substance

**Definition:** A selective effector cell activator protein and agonist of the intermediate-affinity interleukin-2 (IL-2) receptor with potential immunostimulating and antineoplastic activity. Upon administration, nemvaleukin alfa binds to and signals through the intermediate-affinity IL-2 receptor complex; this may selectively stimulate and activate natural killer (NK) cells and memory CD8 T-cells, leading to tumor cell elimination, while circumventing the activation of immunosuppressive cells that may prevent the anti-tumor response. IL-2 is a cytokine signaling molecule that plays a critical role in the immune response.

**Synonyms:** - ALKS 4230 - Intermediate-affinity IL-2R Agonist ALKS 4230 - Intermediate-affinity Interleukin-2 Receptor Agonist ALKS 4230 - NEMVALEUKIN ALFA - RDB 1450 - RDB-1450