Platelet-Derived Growth Factor-AA

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A disulfide-linked homodimeric protein complex comprised of 2 platelet-derived growth factor subunit A proteins. This dimeric growth factor binds to a homodimeric receptor comprised of two platelet-derived growth factor receptor alpha proteins. Ligand binding activates the intrinsic tyrosine-protein kinase activity of the receptor complex and initiates signal transduction pathways.

**Synonyms:** - PDGF-AA