pan-PIM Kinase Inhibitor NVP-LGB-321

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available, small molecule and selective ATP-competitive pan-inhibitor of proviral integration sites for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, pan-PIM kinase inhibitor NVP-LGB-321 binds to and prevents the activation of the three PIM family kinases, PIM1, PIM2 and PIM3. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIMs. PIMs, constitutively active proto-oncogenic serine/threonine kinases upregulated in various types of cancers, play key roles in tumor cell proliferation and survival.

**Synonyms:** - LGB321 - NVP-LGB-321 - PIM Inhibitor NVP-LGB-321 - PIM Kinase Inhibitor NVP-LGB-321