Idarucizumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal antibody fragment directed against the thrombin-binding site of dabigatran, that may be used as a specific reversal agent for dabigatran. Upon intravenous administration, idarucizumab binds to dabigatran and its acylglucuronide metabolites with a higher affinity than the binding affinity of dabigatran to thrombin, thereby neutralizing the anticoagulant effect of dabigatran.

**Synonyms:** - BI 655075 - BI-655075 - BI655075 - IDARUCIZUMAB - Praxbind