NCIt Antineoplastic Agent Terminology

**Semantic type:** Intellectual Product

**Definition:** A terminology subset in NCI Thesaurus (NCIt) containing any agent that has known or potential antineoplastic activity. The subset includes FDA approved antineoplastic agents, agents that either are or once were in clinical trial (CT) specifically for their antineoplastic activity as well as some additional investigational agents that may have antineoplastic activity. Included in this list are conventional antineoplastic agents, specific tumor-targeting agents, and cancer immunotherapeutics. Excluded from this list are: agents that treat cancer-related conditions; cancer diagnostics or agents used for tumor imaging; agents that treat drug-related adverse effects; any agent that increases an antineoplastic agent's efficacy or pharmacokinetic profile but does not have an antineoplastic effect by itself, including immunoadjuvants that boost efficacy of antineoplastic vaccines; and antineoplastic agents that are conjugated with a radioisotope and are in CT for efficacy and/or ADME studies.