Thrombomodulin Alfa

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A recombinant, soluble form of the human protein thrombomodulin, with potential anticoagulant activity. Upon administration, thrombomodulin binds to thrombin, which stimulates the activation of protein C. Activated protein C (APC) degrades factor Va and Factor VIIa in the presence of the cofactor protein S, inhibits thrombin formation, and prevents both thrombin-mediated coagulation and further clot formation.

**Synonyms:** - 1-498-Thrombomodulin (Human Clone TMP26/TMJ1 Protein Moiety Reduced) - ART 123 - ART-123 - Recomodulin - THROMBOMODULIN ALFA - Thrombomodulin (Human 498-Amino Acid Fragment)