Activating RAS Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A mutation in a RAS family gene (HRAS, KRAS or NRAS) that causes the encoded GTPase to be resistant to GTP hydrolysis and results in constitutive activation of its activity and downstream pathways.

**Synonyms:** - Activating RAS - Activating RAS Family Gene Mutation - Activating RAS Family Mutation - Activating RAS Gene Mutation