DLX5 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human DLX5 wild-type allele is located in the vicinity of 7q21.3 and is approximately 5 kb in length. This allele, which encodes homeobox protein DLX-5, plays a role in transcriptional activation that is essential for osteoblast differentiation. Mutation of the gene is associated with split-hand/foot malformation 1 with sensorineural hearing loss.

**Synonyms:** - Distal-Less Homeo Box 5 Gene - Distal-Less Homeobox 5 wt Allele - SHFM1D - Split Hand/Foot Malformation Type 1 With Sensorineural Hearing Loss Gene